Proteomic analysis of pediatric sinonasal secretions shows increased MUC5B mucin in CRS.

Background: Chronic rhinosinusitis (CRS) is characterized by mucous overproduction and submucosal gland hyperplasia. The global protein profile of sinonasal secretions in pediatric CRS has not been studied. We hypothesized that MUC5B, a glandular mucin, would be relatively increased in CRS secretions compared to other mucins.

Propranolol-mediated attenuation of MMP-9 excretion in infants with hemangiomas.

Importance: Infantile hemangiomas (IHs) vary substantially in localization and extent of tissue involvement, but IH biological progression is remarkably unique and predictable. Propranolol is an effective treatment for symptomatic IH, but its mechanism of action remains unknown and understudied.

Objective: To compare excreted proteins in infants with IH being treated with propranolol vs prednisolone.