Targeting AKT2 in MDA-MB-231 Cells by Pyrazole Hybrids: Structural, Biological and Molecular Docking Studies.

Pyrazolic hybrids appended with naphthalene, p-chlorobenzene, o-phenol and toluene have been synthesized using Claisen Schmidt condensation reaction of 1-benzyl-3,5-dimethyl-1H-pyrazole-4-carbaldehyde. All compounds were characterized by various spectroscopic techniques. Compound (E)-3-(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-1-(4-chlorophenyl)prop-2-en-1-one crystallizes in monoclinic crystal system with C2/c space group.

Copper-Catalyzed Direct Thiolation of Ketones Using Sulfonohydrazides: A Synthetic Route to Benzylic Thioethers.

A facile copper-catalyzed sustainable thiolation of ketones with sulfonohydrazides has been designed for the efficient construction of benzylic thioethers in excellent yield under mild reaction conditions. The current approach avoids the widely used thiolation reagent, thiols. The commercial availability of the base and reagents, broad substrate scope, and convenient reaction procedure make it an attractive method for benzylic thioether synthesis.