Chemical characterization, assessment of acute oral toxicity, and antinociceptive potential of the methanolic extract of (Arruda) Schott leaves from Brazil.

Background: (Arruda) Schott is popularly known as "aninga," "aningaçu," "aningaíba," and "aninga-do-igapó." Compresses and plasters made from the leaves of this medicinal plant are used to treat abscesses, tumors, and pain caused by stingray stings.

Aim Of The Study: This study aimed to chemically characterize the methanolic extract of leaves (MEMLL), as well as to verify their acute oral toxicity and antinociceptive potential.

Tea tree essential oil and its impact on blue mold, volatile compounds, and postharvest quality of 'Fuji' apples: A study of laboratory-extracted and commercial essential oils.

This study evaluated the effects of tea tree essential oil (TTO) on blue mold severity, volatile compound profiles, and postharvest quality of 'Fuji' apples during cold storage. Two experiments were conducted using laboratory-extracted TTO from Brazil and commercial TTO from Australia, applied by vaporization at various concentrations. Both types of TTO affected major volatile compounds, including terpinen-4-ol, γ-terpinene, and α-terpinene.

Implementation of a Multidisciplinary Team to Improve the Quality of Care for Older Surgical Patients at a Rural Academic Medical Center.

For the first time in history, people age older than 65 years make up >20% of the non-metro population, compared with 16% of the metro population. From 2010 to 2020 the nonmetro population age older than 65 years grew by 22%, while the working-age population declined by 4.9%, and the population aged under 18 years declined by 5.

Trends in study topics related to quality of life in Industry 4.0: A bibliometric analysis.

Background: The use of new technologies boosted Industry 4.0, making processes more sophisticated and considering the interaction between physical production systems and workers. But these new technologies also intervene in the worker's quality of life (QoL), that is, we need to know if the industry of the future is changing the scenario of the present.

Health-related quality of life in children with cerebral palsy associated with congenital Zika infection.

Objective: To describe the health-related quality of life (QOL) in children with cerebral palsy (CP) associated with congenital Zika infection.

Methods: Cross-sectional study of a consecutive series of children, followed in a referral multicentric rehabilitation network in Brazil. We invited the caregivers to respond to the Brazilian version of the Caregiver Priorities & Child Health Index of Life with Disabilities (CPCHILDTM) questionnaire.

Studies on the Phytochemical Profile of var. (L.) Alef. Essential Oil, Its Larvicidal Activity and In Silico Interaction with Acetylcholinesterase against (Diptera: Culicidae).

L. (Diptera: Culicidae) is an important transmitter of diseases in tropical countries and controlling the larvae of this mosquito helps to reduce cases of diseases such as dengue, zika and chikungunya. Thus, the present study aimed to evaluate the larvicidal potential of the essential oil (EO) of var.

Neurodevelopmental outcomes in a cohort of children with congenital Zika syndrome at 12 and 24 months of age.

Background: Early child development is a critical stage of life that influences social, educational and health outcomes worldwide. A few years after Zika epidemic, families of children born with congenital Zika syndrome (CZS) continue to face uncertainties when it comes to the development of their children. The present study sought to analyse the developmental trajectories of a subset of children born with CZS in the first 24 months of life.

Biochar mitigates bioavailability and environmental risks of arsenic in gold mining tailings from the eastern Amazon.

Artisanal gold mining has generated tailings highly contaminated by arsenic (As) in Cachoeira do Piriá, eastern Amazon, leading to severe risks to the environment. Such risks should be mitigated considering the bioavailable concentration of the element, since it implies immediate damage to the ecosystem. The objective of this study was to evaluate the potential of biochars in mitigating the environmental risks of bioavailable As concentrations in gold mining tailings from underground and cyanidation exploration.

Doxycycline Decreases Atherosclerotic Lesions in the Aorta of and Ovariectomized Mice with Correlation to Reduced MMP-2 Activity.

Atherogenic events promote changes in vessel walls, with alteration of the redox state, and increased activity of matrix metalloproteinases (MMPs). Thus, this study aims to evaluate aortic remodeling, MMP activity, and reactive oxygen species (ROS) levels after treatment with doxycycline in ApoE-⁄- and ovariectomized mice (OVX). Female ApoE-⁄--knockout mice (5 weeks) were submitted to ovariectomy surgery to induce experimental menopause.

Impact of copper mining wastes in the Amazon: Properties and risks to environment and human health.

Improper disposal of copper mining wastes can threaten the ecosystem and human health due to the high levels of potentially toxic elements released into the environment. The objective of this study was to determine the properties of Cu mining wastes generated in the eastern Amazon and their potential risks to environment and human health. Samples of forest soil and artisanal/industrial Cu mining wastes were collected and subjected to characterization of properties and pseudo-total concentrations of Al, As, Ba, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, and Zn, in addition to chemical fractionation of Cu.

Biochemical metabolism of young plants of Ucuúba (Virola surinamensis) in the presence of cadmium.

Virola surinamensis is a forest species widely distributed in the estuaries of the Amazon. These ecosystems are susceptible to contamination by Cadmium (Cd), indicating that the plant has strategies for tolerating this metal. The aim of this study was to assess the nitrogen and carbon metabolism of young plants of Ucuúba (Virola surinamensis) in the presence of cadmium with the perspective of the phytoremediation of contaminated environments.

Environmental and human health risks of arsenic in gold mining areas in the eastern Amazon.

Knowledge of arsenic (As) levels in gold (Au) mining areas in the Amazon is critical for determining environmental risks and the health of the local population, mainly because this region has the largest mineral potential in Brazil and one of the largest in the world. The objective of this study was to assess the environmental and human health risks of As in tailings from Au exploration in the eastern Amazon. Samples were collected from soils and tailings from different exploration forms from 25 points, and the total concentration, pollution indexes and human health risk were determined.

Phytoremediation potential of Khaya ivorensis and Cedrela fissilis in copper contaminated soil.

Mineral exploration of copper (Cu) in the Amazon has significantly impacted the environment, leading to contamination of large areas that require remediation. Tropical tree species that can immobilize metals and restore plant cover should be selected for phytoremediation programs. The phytoremediation behavior of Khaya ivorensis and Cedrela fissilis was studied in Cu contaminated soil (60, 200, 400, and 600 mg kg).

Phosphorus lability increases with the rehabilitation advance of iron mine land in the eastern Amazon.

Impacted areas by iron mining may face challenges in the management of phosphate fertilization and reduced efficiency of rehabilitation practices, thus extending the time required for the rehabilitation of these areas. The objective of this study was to evaluate phosphorus (P) lability in soils of native forest and ferriferous canga areas (savanna vegetation above ironstone outcrops covering iron ore deposits) and in iron mine waste piles undergoing rehabilitation. Benches of the analysed waste pile differ in age of rehabilitation: as the initial rehabilitation stage (INI), we consider benches with fewer than 3 years of rehabilitation; the intermediate stage (INT) were benches with up to 5 years of rehabilitation; and the advanced rehabilitation stage (ADV) corresponds to benches with more than 8 years of rehabilitation activities.

Chemical fractionation and bioaccessibility of potentially toxic elements in area of artisanal gold mining in the Amazon.

Artisanal mining may have modified the mobility, bioavailability and bioaccessibility of potentially toxic elements (PTEs) in the Serra Pelada gold mine, eastern Amazon, Brazil, which has not yet been studied. The objectives were to perform chemical fractionation of barium (Ba), chromium (Cr), copper (Cu), nickel (Ni), lead (Pb), and zinc (Zn), and to determine the bioaccessibility of these elements in soils and mining wastes collected in agriculture, forest, mining, and urban areas from the influence zone of the Serra Pelada gold mine. Pseudo total concentrations were obtained by acid digestion, chemical fractionation was performed using the Bureau Community of Reference (BCR) sequential extraction, oral bioaccessibility was obtained by the Simple Bioaccessibility Extraction Test (SBET) and lung bioaccessibility was obtained through Gamble's solution.

Changes in visual function and retinal structure in the progression of Alzheimer's disease.

Background: Alzheimer's Disease (AD) can cause degeneration in the retina and optic nerve either directly, as a result of amyloid beta deposits, or secondarily, as a result of the degradation of the visual cortex. These effects raise the possibility that tracking ophthalmologic changes in the retina can be used to assess neurodegeneration in AD. This study aimed to detect retinal changes and associated functional changes in three groups of patients consisting of AD patients with mild disease, AD patients with moderate disease and healthy controls by using non-invasive psychophysical ophthalmological tests and optical coherence tomography (OCT).

Aqueous Coriandrum sativum L. extract promotes neuroprotection against motor changes and oxidative damage in rat progeny after maternal exposure to methylmercury.

This study aimed to investigate the effects of Coriandrum sativum aqueous extract (CSAE) on the rat progeny of mothers exposed to methylmercury (MeHg). The presence of bioactive compounds and CSAE's antioxidant capacity been evaluated, and the offspring were assessed for their total mercury levels, motor behavioral parameters and oxidative stress in the cerebellum. The analysis of the bioactive compounds revealed significant amounts of polyphenols, flavonoids, and anthocyanins, as well as a variety of minerals.

(Mart.) Kausel: toxicological assays, biological activities, and elemental analysis of organic compounds.

Jaboticaba, (Mart.) Kausel, is a Brazilian berry traditionally used in folk medicine as treatment for some health conditions. Phenolic compounds such as flavonoids and anthocyanins have previously been detected in the fruit.

Effect of cadmium on young plants of .

The steady increase in cadmium (Cd) levels in the environment from anthropogenic actions has contributed to environmental degradation. is a forest species that has desirable characteristics such as deep and dense roots, relatively rapid growth and high biomass production to remedy contaminated environments by Cd. The aim of this study was to assess the physiological responses and the phytoextraction and tolerance capacity of young plants of submitted to Cd concentrations.

Phenolic Content and Antioxidant Activity during the Development of 'Brookfield' and 'Mishima' Apples.

The aim of this study was to characterize the changes in the contents of total (TPC) and individual (IPC) phenolic compounds, the total antioxidant activity (TAA) in the peel and pulp, and total anthocyanins (TAN) in the peel during the development of the fruits of 'Brookfield' and 'Mishima' apple trees. 'Brookfield' apples were harvested from the 49th to the 138th days after full bloom (DAFB) and 'Mishima' apples from the 45th to the 172th DAFB. In the pulp, the IPC, TPC, and TAA rapidly reduced at 75 and 79 DAFB for the 'Brookfield' and 'Mishima' apples, respectively, and then remained constant until commercial maturity.

Factors associated with parasite dominance in fishes from Brazil.

The present study used regression models to evaluate the existence of factors that may influence the numerical parasite dominance with an epidemiological approximation. A database including 3,746 fish specimens and their respective parasites were used to evaluate the relationship between parasite dominance and biotic characteristics inherent to the studied hosts and the parasite taxa. Multivariate, classical, and mixed effects linear regression models were fitted.

Parasite abundance and its determinants in fishes from Brazil: an eco-epidemiological approach.

The variability in parasite abundance has an ecological basis; however, from an epidemiological point of view, the contribution of factors inherent to the host to the variability in parasite abundance remains an open question. A database consisting of 3,746 specimens of 73 fish species was used to verify the relation between the distribution of parasite abundance in fishes and a set of biotic factors inherent to the hosts. Classical and mixed Poisson regression models were constructed.

Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumab.

TNF alpha antagonist-induced lupus-like syndrome is a rare condition which predominantly affects women (4:1). The average age of onset is 46-51 years. It occurs after exposure to TNF alpha antagonist and disappears after discontinuation of such agents.

Factors associated with parasite aggregation levels in fishes from Brazil.

The degree of parasite aggregation is determined by a number of factors that are not well understood. In total, 3,746 fish from 73 species and their parasites were analyzed to determine associations between the degree of aggregation by taxon and specific characteristics of the fish. A multiple linear regression (95% confidence interval - CI) was used to show that in most taxa, the degree of parasite aggregation was significantly higher in freshwater fish and schooling fish but varied according to taxon in relation to gender, habitat and feeding habits.