Exploring the Interaction of 3-Hydroxy-4-pyridinone Chelators with Liposome Membrane Models: Insights from DSC and EPR Analysis.

In this study, we synthesized a series of 3-hydroxy-4-pyridinone (3,4-HPO) chelators with varying lipophilicity by modifying the length of their alkyl chains. To investigate their interaction with lipid membranes, we employed differential scanning calorimetry (DSC) and electron paramagnetic resonance (EPR) spectroscopy using dimyristoylphosphatidylcholine (DMPC) and palmitoyloleoylphosphatidylcholine (POPC) liposomes as membrane model systems. DSC experiments on DMPC liposomes revealed that hexyl-substituted chelators significantly altered the thermotropic phase behavior of the lipid bilayer, indicating their potential as membrane property modulators.

High-intensity interval training improves hepatic redox status via Nrf2 downstream pathways and reduced CYP2E1 expression in female rats with cisplatin-induced hepatotoxicity.

Cisplatin (CP) is an antineoplastic drug associated with various cytotoxic adverse effects, including hepatotoxicity. Exercise training may offer hepatoprotection by improving redox status. This study compared the effects of light-intensity continuous training (LICT), moderate-intensity continuous training (MICT), and high-intensity interval training (HIIT) on CP-induced hepatotoxicity in female Wistar rats.

Community-based epilepsy care in an onchocerciasis-endemic area: A 3-year cohort study in Mahenge, Tanzania.

Objective: In onchocerciasis-endemic areas, limited access to antiseizure medications (ASMs) contributes to a high epilepsy burden. This study evaluated the impact of a community-based epilepsy care program in Mahenge, Tanzania, an onchocerciasis-endemic area with high epilepsy prevalence.

Methods: A baseline survey (2017-2018) identified persons with epilepsy (PWE) in four rural villages.

Post-COVID-19 inflammation and sarcopenia in obese diabetic dialysis patients.

Introduction: Diabetes, obesity, and CKD collectively impact musculoskeletal health and increase the risk of severe coronavirus disease 2019 (COVID-19) outcomes.

Methods: This cross-sectional study included 32 dialysis patients, categorized based on their COVID-19 status. Laboratory assessments included inflammatory markers (IL-1β, IL-6, IL-8, and TNF-α).

Ethical considerations in utilizing artificial intelligence for analyzing the NHGRI's History of Genomics and Human Genome Project archives.

Understanding "how to optimize the production of scientific knowledge" is paramount to those who support scientific research-funders as well as research institutions-to the communities served, and to researchers. Structured archives can help all involved to learn what decisions and processes help or hinder the production of new knowledge. Using artificial intelligence (AI) and large language models (LLMs), we recently created the first structured digital representation of the historic archives of the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health.

Portuguese translation, cultural adaptation and psychometric properties of the temporomandibular joint scale: a cross-sectional study.

Background: The temporomandibular joint (TMJ) scale assesses the severity of temporomandibular joint disorders (TMD), yet a European Portuguese translation is lacking.

Objectives: To translate, cross-culturally adapt and to examine the psychometric properties (construct validity and reliability) of the TMJ scale.

Methods: Translation and cultural adaptation were carried out according to international recommendations, including initial translation, evaluation of this translation and cultural adaptation by a panel of experts, and back translation.

Screening and validating the optimal panel of housekeeping genes for 4T1 breast carcinoma and metastasis studies in mice.

The 4T1 model is extensively employed in murine studies to elucidate the mechanisms underlying the carcinogenesis of triple-negative breast cancer. Molecular biology serves as a cornerstone in these investigations. However, accurate gene expression analyses necessitate data normalization employing housekeeping genes (HKGs) to avert spurious results.

Robust extraction of pneumonia-associated clinical states from electronic health records.

Mining of electronic health records (EHR) promises to automate the identification of comprehensive disease phenotypes. However, the realization of this promise is hindered by the unavailability of generalizable ground-truth information, data incompleteness and heterogeneity, and the lack of generalization to multiple cohorts. We present here a data-driven approach to identify clinical states that we implement for 585 critical care patients with suspected pneumonia recruited by the SCRIPT study, which we compare to and integrate with 9,918 pneumonia patients from the MIMIC-IV dataset.

β-Carboline-3-carboxamide Antimalarials: Structure-Activity Relationship, ADME-Tox Studies, and Resistance Profiling.

The development of parasite resistance to both artemisinin derivatives and their partner drugs jeopardizes the effectiveness of the artemisinin combination therapy. Thus, the discovery of new antimalarial drugs, with new mechanisms of action, is urgently needed. We recently disclosed that β-carboline was orally efficacious in -infected mice and that it showed low cross-resistance between susceptible and four different drug-resistant strains.

Wastewater treatment plants circular performance models evaluation: Portugal case-study.

Population growth, economic growth, and changes in societal habits have led to significant changes in resource consumption. Therefore, it's crucial to accelerate the "reduce, reuse, recycle, and recover" of resources to ensure the balance of ecosystems, and water is surely one of the most fundamental resources. The acceleration of this approach in the water cycle makes sense only if we combine a circular economy (CE) transition with a sustainable perspective.

Effect of home-based isometric training on blood pressure in older adults with high normal BP or stage I hypertension: A randomized controlled trial.

Objective: This trial analyzes the effects of home-based isometric handgrip training (IHT) and aerobic exercise training (AET) on ambulatory and office blood pressure (BP) in older adults with high normal to established hypertension.

Methods: This randomized controlled trial included 84 participants (46 women, 71.1 ± 3.

Treated wastewater reuse for irrigation: A feasibility study in Portugal.

In an increasing water scarcity and climate-vulnerable global context, treated wastewater represents a vital alternative water source, thereby enhancing resource sustainability. Despite its potential, only roughly 2.5 % of the treated wastewater is reused in the European Union, with Portugal's reuse rate being only 1.

Cluster classification of a Brazilian gastric cancer cohort reveals remarkable populational differences in normal p53 rate.

Background: Queiroz et al. showed that the application of cluster methodology for classifying gastric cancer is suitable and efficient within a Brazilian cohort, which is known for its population heterogeneity. The study highlighted the potential utilization of this method within public health services due to its low-cost, presenting a viable means to improve the diagnosis and prognosis of gastric cancer.

High-intensity interval training alleviates liver inflammation by regulating the TLR4/NF-κB signaling pathway and M1/M2 macrophage balance in female rats with cisplatin hepatotoxicity.

Cisplatin (CDDP) is an antineoplastic drug whose adverse effects include hepatotoxicity. The inflammatory process is crucial in the progression of liver injuries. Exercise is known for its anti-inflammatory effects, but the influence of different training modalities on hepatoprotection is still unclear.

Decision tree model development and in silico validation for avoidable hospital readmissions at 30 days in a pediatric population.

Background and objective: identifying patients at high risk of avoidable readmission remains a challenge for healthcare professionals. Despite the recent interest in Machine Learning in this topic, studies are scarce and commonly using only black box algorithms. The aim of our study was to develop and validate in silico an interpretable predictive model using a decision tree inference to identify pediatric patients at risk of 30-day potentially avoidable readmissions.

Light-Intensity Physical Activity and Sedentary Behavior Are Associated With Blood Pressure Levels in Adolescents.

Purpose: To investigate the associations between physical activity (PA) intensities, sedentary behavior (SB), and blood pressure (BP) in adolescents, according to sex.

Method: This cross-sectional study involved 95 male and female adolescents aged 15-18 years. Accelerometry was used to measure time spent in light-intensity PA (LPA), moderate to vigorous PA (MVPA), and vigorous PA, and SB.

Gastrotheca Fitzinger, 1843 tadpole morphology: Larval cranium description and its evolutionary implications (Amphibia: Anura: Hemiphractidae).

Hemiphractids have a singular mode of reproduction that involves maternal care. The Andean-endemic Gastrotheca marsupiata species group includes direct-developing and tadpole-bearing species, the latter trait being unique among Gastrotheca. Larval morphology has proven to be a valuable source of evidence to understand the taxonomy and evolution of frogs but remains understudied in Hemiphractids.

Analysis of Macronutrients in Soil Using Impedimetric Multisensor Arrays.

The need to increase food production to address the world population growth can only be fulfilled with precision agriculture strategies to increase crop yield with minimal expansion of the cultivated area. One example is site-specific fertilization based on accurate monitoring of soil nutrient levels, which can be made more cost-effective using sensors. This study developed an impedimetric multisensor array using ion-selective membranes to analyze soil samples enriched with macronutrients (N, P, and K), which is compared with another array based on layer-by-layer films.

Polysaccharides extracted from tucum-do-cerrado fruits (Bactris setosa Mart) have antineoplastic effects in mice while preserving hepatic gluconeogenesis.

This study investigated the antitumoral, anti-inflammatory and oxidative effects of polysaccharides from tucum (Bactris setosa, TUC) using the Ehrlich carcinoma as a tumor model. Additionally, the glycogen content, cytochrome P levels, and gluconeogenesis from lactate were assessed in the liver of healthy animals. Tumor-bearing female mice were orally treated with 50 and 100 mg.

A versatile yeast model identifies the pesticides cymoxanil and metalaxyl as risk factors for synucleinopathies.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of Lewy bodies, which predominantly consist of aggregated forms of the protein alpha-synuclein (aSyn). While these aggregates are a pathological hallmark of PD, the etiology of most cases remains elusive. Although environmental risk factors have been identified, such as the pesticides dieldrin and MTPT, many others remain to be assessed and their molecular impacts are underexplored.

Longitudinal stability of individual brain plasticity patterns in blindness.

The primary visual cortex (V1) in blindness is engaged in a wide spectrum of tasks and sensory modalities, including audition, touch, language, and memory. This widespread involvement raises questions regarding the constancy of its role and whether it might exhibit flexibility in its function over time, connecting to diverse network functions specific to task demands. This would suggest that reorganized V1 assumes a role like multiple-demand system regions.