Coexistence of sickle cell disease and systemic lupus erythematosus is associated with quantitative and qualitative impairments in circulating regulatory B cells.

The incidence of connective tissue diseases such as systemic lupus erythematous (SLE), in adult patients with sickle cell disease (SCD), appears to be increasing. The exact causes underlying this increased risk are still unknown, but a link with B regulatory (Breg) cells is possible as these cells suppress inflammatory responses, and maintain tolerance. Quantitative and qualitative analyses of circulating Breg cells were performed in a cohort of SCD patients with SLE, and their levels were correlated with key soluble mediators promoting autoreactive B cells.

A Surrogate Water Quality Index to assess groundwater using a unified DEA-OWA framework.

In this paper, we introduce a new approach, based on a unified framework incorporating Data Envelopment Analysis (DEA) and Ordered Weighted Averaging (OWA), for assessing water quality in contextual settings that involve a large number of hydrochemical parameters. In order to enhance discrimination among water sources, the DEA model is adopted with data-driven input variables, called "surrogate optimistic closeness values," computed through an aggregation procedure that includes the observed values of the hydrochemical parameters with OWA weights. The proposed DEA-OWA methodology has been employed to assess the quality of 51 water samples, collected from irrigation wells in Sereflikochisar Basin, Turkey, by means of 19 hydrochemical parameters.

An integrated approach for assessing surface water quality: Case of Beni Haroun dam (Northeast Algeria).

In this paper, we use an integrated approach to carry out a comprehensive evaluation of water quality in the Beni Haroun (BH) dam, the largest surface water resource in Algeria. Several techniques have been employed under the same framework, including the Canadian Council Ministers Environment Water Quality Index (CCME-WQI), principal component analysis and factor analysis (PCA/FA), the K-means clustering, and the ordinary least square (OLS) analysis. A data set of 22 physicochemical parameters has been collected, over a period of 11 years, from three sampling stations: Ain Smara (ST1) and Menia (ST2), both located upstream of "Wadi Rhumel," and BH dam station (ST3), located at the dam site.