A novel μ-CO bridged linear polymeric Cu-complex ([Cu(DMAP)(μ-CO)]I) ·HO: synthesis, characterization and catalytic applications in the synthesis of phenoxypyrimidines and arylthiopyrimidines C-O and C-S cross-coupling reactions.

This manuscript reports on the synthesis and characterization of a new polymeric copper complex ([Cu(DMAP)(μ-CO)]I) ·HO and its successful application in C-O and C-S cross coupling reactions for the synthesis of biologically important phenoxypyrimidine and arylthiopyrimidine scaffolds. In an attempt to synthesize [Cu(DMAP)I]I by adopting a procedure reported by Roy with slight modification, the authors discovered a new polymeric Cu-complex that contains μ-CO bridges. The polymeric linear structure of the complex was established using single crystal X-ray analysis.

Copper-Catalyzed Direct Syntheses of Phenoxypyrimidines from Chloropyrimidines and Arylboronic Acids: A Cascade Avenue and Unconventional Substrate Pairs.

This letter describes the first synthetic methodology for phenoxypyrimidines that avoids the direct use of phenols or their salts. In contrast to the general trend of delivering Suzuki-Miyaura cross-coupling products in reactions between aryl or alky halides and arylboronic acids, the substrate pairs used herein (chloropyrimidines and arylboronic acids) led to C-O bond formation under the reaction conditions. In total, 25 phenoxypyrimidines were successfully synthesized using the described protocol, 6 of which had a structural resemblance to etravirine.