Publications by authors named "Amar J"

Article Synopsis
  • Cervical artery dissection (CeAD) is a leading cause of ischemic strokes in young adults, and this study explored the effects of intravenous thrombolysis (IVT) on patients with CeAD and stroke symptoms.
  • Analyzed data from the STOP-CAD study, it found that IVT significantly improved functional independence after 90 days in patients without increasing the risk of symptomatic intracranial hemorrhage.
  • The results suggest that IVT is a beneficial treatment for eligible patients with CeAD, aligning with current medical guidelines on its use.
View Article and Find Full Text PDF

While the dominant defects which control non-radiative recombination and long-range interstitial diffusion in CdTe correspond to Cd vacancies and Te anti-sites, the short-range diffusion of Te and Se interstitials between these defects is also of interest, since they both play a role in defect passivation. In addition, since CdTe thin films are typically polycrystalline and may also involve interfaces with materials with different lattice constants, the effects of strain are also of interest. Here we present the results of molecular dynamics (MD) simulations of Te interstitial diffusion in zincblende CdTe for values of the triaxial strain ranging from -2% (compressive) strain to +2.

View Article and Find Full Text PDF

Intervention programs aimed at mitigating the effects of chronic noncommunicable disease (CNDs) focus on promoting healthy lifestyle habits (HLH), especially in the early stages of life. Because of this, different typologies of caregivers have been identified according to HLH during middle childhood and adolescence. However, the available studies have focused on aspects such as nutrition, physical activity, and rest, ignoring other HLHs that are equally important for children's well-being.

View Article and Find Full Text PDF

Island nucleation and growth play an important role in thin-film growth. One quantity of particular interest is the exponent χ, which describes the dependence of the saturation island density N_{sat}∼(D_{h}/F)^{-χ} on the ratio D_{h}/F of the monomer hopping rate D_{h} to the deposition rate F. While standard rate equation (RE) theory predicts that χ=i/(i+2) (where i is the critical island size), more recently it has been predicted that in the presence of a strong barrier to the attachment of monomers to islands, a significantly larger value χ=2i/(i+3) may be observed.

View Article and Find Full Text PDF

Long-standing facial palsy sequelae cause functional, aesthetic, and psychological problems in patients. Botulinum toxin is an effective way to manage them, but no standardized recommendations exist. Through this non-systematic review, we aimed to guide any practitioner willing to master the ins and outs of this activity.

View Article and Find Full Text PDF

(1) Background: Sequels of facial palsy lead to major psychosocial repercussions, disrupting patients' quality of life (QoL). Botulinum toxin (BoNT) injections can permit us to treat long-standing facial palsy, improving facial symmetry and functional signs including synkinesis and contractures. (2) Methods: The main aim of this study was to assess the evolution of the QoL for patients with long-standing facial palsy before, at 1 month, and at 4 months after BoNT injections by using three questionnaires (HFS-30, FaCE, and HAD).

View Article and Find Full Text PDF

Background: Digital health programs provide individualized support to patients with chronic diseases and their effectiveness is measured by the extent to which patients achieve target individual clinical outcomes and the program's ability to sustain patient engagement. However, patient dropout and inequitable intervention delivery strategies, which may unintentionally penalize certain patient subgroups, represent challenges to maximizing effectiveness. Therefore, methodologies that optimize the balance between success factors (achievement of target clinical outcomes and sustained engagement) equitably would be desirable, particularly when there are resource constraints.

View Article and Find Full Text PDF

Background: Small, randomized trials of patients with cervical artery dissection showed conflicting results regarding optimal stroke prevention strategies. We aimed to compare outcomes in patients with cervical artery dissection treated with antiplatelets versus anticoagulation.

Methods: This is a multicenter observational retrospective international study (16 countries, 63 sites) that included patients with cervical artery dissection without major trauma.

View Article and Find Full Text PDF
Article Synopsis
  • - Convolutional neural networks (CNNs) are advanced deep learning algorithms primarily used for visual recognition, showing accuracy in identifying melanomas that matches or exceeds that of dermatologists, even though only 23.8% of dermatologists have solid understanding of AI.
  • - The study explores the use of CNNs in differentiating between benign and malignant lesions, highlighting their ability to perform preprocessing, segmentation, feature extraction, and classification in one efficient process.
  • - It suggests the need for more research to enhance the clinical use of AI, develop extensive datasets, and produce explainable algorithms for better understanding and acceptance in the medical community.
View Article and Find Full Text PDF

Introduction: All that wheezes is not asthma. Although, asthma is the most common cause of wheeze and cough in children and adults, it is often attributed inappropriately to these symptoms from other causes.

Aim: We illustrate through this manuscript three rare causes of wheeze in adults, misdiagnosis as asthma.

View Article and Find Full Text PDF

Adoption of high-content omic technologies in clinical studies, coupled with computational methods, has yielded an abundance of candidate biomarkers. However, translating such findings into bona fide clinical biomarkers remains challenging. To facilitate this process, we introduce Stabl, a general machine learning method that identifies a sparse, reliable set of biomarkers by integrating noise injection and a data-driven signal-to-noise threshold into multivariable predictive modeling.

View Article and Find Full Text PDF

Oral squamous cell carcinoma (OSCC), a prevalent and aggressive neoplasm, poses a significant challenge due to poor prognosis and limited prognostic biomarkers. Leveraging highly multiplexed imaging mass cytometry, we investigated the tumor immune microenvironment (TIME) in OSCC biopsies, characterizing immune cell distribution and signaling activity at the tumor-invasive front. Our spatial subsetting approach standardized cellular populations by tissue zone, improving feature reproducibility and revealing TIME patterns accompanying loss-of-differentiation.

View Article and Find Full Text PDF

Introduction: Despite therapeutic advances, morbidity attributed to asthma continues to increase. This seems partly to be due to poor adherence.

Aim: To assess therapeutic adherence and the association between poor compliance and asthma control.

View Article and Find Full Text PDF

Introduction: Radiologically negative subarachnoid hemorrhage (SAH) has a low incidence and is associated with good clinical outcomes.

Case Report: We present the case of a 44-year-old male with new-onset headaches, which began one week prior while bike riding. At an outside hospital, he had normal computed tomography head and angiogram.

View Article and Find Full Text PDF

Background: Left ventricular hypertrophy is often associated with hypertension, which is not necessarily the cause of hypertrophy. Non-hypertension-related aetiologies often have a strong impact on patient management, and therefore require a thorough and careful workup. When considering all left ventricular hypertrophies, even the mild ones, the number of patients who need a workup increases drastically.

View Article and Find Full Text PDF
Article Synopsis
  • * Advanced statistical techniques were applied to analyze liver samples, revealing that a large proportion of early-stage fibrosis taxa belonged to families like Enterobacteriaceae and Pseudomonadaceae, while specific microbial pathways were linked to different fibrosis scores.
  • * The findings suggest that bacteria may contribute to fibrosis progression, particularly in its early stages, and highlight the effectiveness of improved statistical methods to analyze microbiota data despite varying sample sizes and origins.
View Article and Find Full Text PDF

Non-ketotic hyperglycemia (NKH) is associated with a spectrum of symptoms and radiographic findings due to poorly-controlled diabetes mellitus. These lesions, which predominantly affect the parieto-occipital cortex, are commonly missed by neurologists and neuroradiologists due to their subtle hypointense appearance on T2-based imaging. We report four atypical cases of this syndrome to highlight its subtle, protean presentation in order to aid timely diagnosis.

View Article and Find Full Text PDF

Painful Hand Seizures are a rarely reported form of secondary sensory seizures (SSS) characterized by painful, bilateral sensorimotor hand involvement and preserved consciousness. We report our case to aid neurologists in recognizing SSS as an atypical presentation of seizures.

View Article and Find Full Text PDF

Background And Objective: Cerebral venous thrombosis (CVT) is a rare cause of stroke carrying a nearly 4% risk of recurrence after 1 year. There are limited data on predictors of recurrent venous thrombosis in patients with CVT. In this study, we aim to identify those predictors.

View Article and Find Full Text PDF

Background: The structured observation summary (SOS) is a method of active case-based learning, whose diagnosis is known to learners.

Aim: To assess the value of SOS in the learning of clinical reasoning in pulmonology among first year students of the second cycle of medical studies.

Methods: This was a descriptive cross-sectional study.

View Article and Find Full Text PDF

Background: The Covid-19 pandemic necessitated a decrease in non-Covid-19 related diagnostic and therapeutic procedures in many countries. We explored the impact on tertiary hypertension care.

Methods: We conducted an electronic survey regarding 6 key procedures in hypertension care within the Excellence Center network of the European Society of Hypertension.

View Article and Find Full Text PDF
Article Synopsis
  • Pheochromocytoma-paragangliomas (PPGL) can cause dangerous heart conditions called catecholamine-induced cardiomyopathy (CIC) due to the release of excessive catecholamines.
  • Genetic differences in adrenergic receptors, particularly the ADRA2C variant (alpha 2CDel322-325), have been linked to increased risk of CIC in patients with PPGL.
  • Identifying patients without this genetic variant can help predict lower risk of developing CIC, aiding doctors in tailoring treatment plans for those at higher risk of complications.
View Article and Find Full Text PDF