Interleukin 16 polymorphism and susceptibility of rheumatoid arthritis disease in Egyptian population.

Rheumatoid arthritis (RA) is a systemic and multiple-stage disorder characterized by chronic inflammation with extensive synovitis. The genetic and environmental factors are associated with the risk for RA development. In RA, the induced IL-16 may play a role in initiating, sustaining and increasing the inflammatory response and development of synovitis, nevertheless IL-16's actual role in RA pathogenesis must be studied further.

Biochemical Analysis of C-X-C Motif Chemokine Ligand 10 (CXCL10) as a Biomarker in Patients with Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is characterized by chronic inflammation and synovial hyperplasia that eventually leads to the destruction of the joints. CXCL10 has been originally identified as a pro-inflammatory chemokine that mediate leukocyte trafficking and modulate innate and adaptive immune responses. It plays a critical role in the inflammatory response and is involved in several biological processes.

25-hydroxyvitamin D Deficiency and Predictive Factors in Patients with Diabetic Nephropathy in Type 2 Diabetes Mellitus.

Diabetes mellitus is a metabolic disease that is characterized by chronic hyperglycemia. Type 2 diabetes is a global health problem and leading to many dangerous complications. Diabetic nephropathy is a significant microvascular complication resulting from diabetes mellitus that is affecting up to 50% of patients with end stage renal disease.

Clinical significance of suppressor of cytokines signalling-3 mRNA expression from patients with non-Hodgkin lymphoma under chemotherapy.

Introduction: To date, little is known about blood immune marker changes that may be related to the development of Non Hodgkin Lymphoma (NHL) and treatment response with few serum biomarkers that could be useful in follow- up of the patients.

Objective: To quantify the expression of suppressor of cytokine signalling-3-(SOCS-3) gene at the mRNA level in the peripheral blood of patients with NHL and correlate with clinical pathological features and response to treatment.

Methods: Thirty patients with NHL and 20 healthy controls were enrolled in the study.