Gastric ulcers are common inflammatory diseases that pose a significant socio-economic challenge, and high-mobility group box 1 (HMGB1) is a key protein involved in their inflammation and development.
The study aimed to explore the protective properties of C-phycocyanin from Spirulina microalgae against ethanol-induced gastric ulcers by targeting the HMGB1/NLRP3/NF-κB pathway.
Results showed that C-phycocyanin reduced inflammatory markers and HMGB1 expression, suggesting it could be an effective treatment for gastric ulcers due to its anti-inflammatory and anti-ulcerogenic effects.