Publications by authors named "Amany Abd-Elhameed Abou-Bakr"
Background: When the resected specimen is sent for intraoperative margin assessment, all margins are grossly checked, and selected margins undergo a frozen section (FS) examination. Therefore, there is a possibility of sampling error. This study evaluated the effectiveness of using toluidine blue (TB) as an intraoperative triage screening tool to detect positive mucosal margins of the resected specimens of oral squamous cell carcinoma (OSCC) and serve as a guide for FS sampling.
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- The incidence of breast cancer is rising in Egypt, but knowledge of the genetic mutations involved in this cancer is limited.
- This study sequenced 409 cancer-related genes in 46 fresh breast tumor samples from Egyptian patients, identifying common somatic mutations and their frequencies.
- Key findings include 15 mutations in one gene and 8 in another, a total of 19 pathogenic mutations overall, and indications that the PI3K/AKT signaling pathway is altered in over 50% of the cases, suggesting it could be a target for treatment.