Publications by authors named "Amanuel Abraha Teklu"
Aging is influenced by a complex interplay of multifarious factors, including an individual's genetics, environment, and lifestyle. Notably, high altitude may impact aging and age-related diseases through exposures such as hypoxia and ultraviolet (UV) radiation. To investigate this, we mined risk exposure data (summary exposure value), disease burden data (disability-adjusted life years (DALYs)), and death rates and life expectancy from the Global Health Data Exchange (GHDx) and National Data Management Center for Health of Ethiopia for each subnational region of Ethiopia, a country with considerable differences in the living altitude.
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- The study investigates the role of cellular senescence in breast cancer development, highlighting its dual nature as both a potential barrier to cancer growth and a promoter of tumor-related inflammation, but notes that understanding in humans is limited due to previous research mainly in non-human models.
- Researchers analyzed breast biopsy samples from healthy women using advanced deep learning techniques to identify senescence markers in different tissue types, aiming to link these markers to breast cancer risk.
- The findings were compared to established breast cancer risk assessment methods (Gail scores) to evaluate the effectiveness of senescence as a predictor for future breast cancer development.
Background: The ability to predict future risk of cancer development in non-malignant biopsies is poor. Cellular senescence has been associated with cancer as either a barrier mechanism restricting autonomous cell proliferation or a tumor-promoting microenvironmental mechanism that secretes pro-inflammatory paracrine factors. With most work done in non-human models and the heterogenous nature of senescence the precise role of senescent cells in the development of cancer in humans is not well understood.
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