Synopsis of recent research by authors named "Amani H Osman"
- Amani H Osman's recent research focuses on the heterogeneity of carcinoma-associated fibroblasts (CAFs) in oral squamous cell carcinoma (OSCC), identifying distinct subtypes with unique tumor-promoting abilities.
- The study distinguishes between two CAF subtypes: CAF-N, which resembles normal fibroblasts, and CAF-D, which exhibits a divergent expression pattern, contributing differently to tumor behavior.
- Findings indicate that both CAF subtypes promote higher tumor incidence and deeper invasion of malignant keratinocytes compared to normal fibroblasts, although CAF-N demonstrates greater efficiency in enhancing tumor incidence than CAF-D.
