Major role of MT receptors in the beneficial effect of melatonin on long-term recognition memory in C57BL/6J male mice.

Melatonin, a major signal of the circadian system, is also involved in brain functions such as learning and memory. Chronic melatonin treatment is known to improve memory performances, but the respective contribution of its central receptors, MT and MT, is still unclear. Here, we used new single receptor deficient MT and MT mice to investigate the contribution of each receptor in the positive effect of chronic melatonin treatment on long-term recognition memory.