Publications by authors named "Amandine Salamagnon"
Article Synopsis
- EMT and primary ciliogenesis together help basal mammary stem cells (MaSCs) gain stem cell properties to support mammary gland development, but the exact processes are still not fully clear.
- EMT transcription factors are found to initiate ciliogenesis during specific EMT stages by activating key inducers like FGFR1, which then leads to the inactivation of the GLIS2 protein, a transcriptional repressor.
- This inactivation of GLIS2 enhances MaSC stemness and is essential for normal mammary gland development, as well as boosting the growth and tumor formation in certain breast cancers, particularly claudin-low subtypes, distinguished by a GLIS2-dependent gene expression pattern.
