Publications by authors named "Amandine Lavaux"
First description of the t(10;11)(q22;q23)/MLL-TET1 translocation in a T-cell lymphoblastic lymphoma, with subsequent lineage switch to acute myelomonocytic myeloid leukemia.
Haematologica
December 2013
According to the current paradigm, lymphocyte homing to the small intestine requires the expression of two tissue-specific homing receptors, the integrin α4β7 and the CCL25 receptor CCR9. In this study, we investigated the organ distribution and the homing molecule expression of IgA Ab-secreting cells (ASCs) induced by intrarectal immunization with a particulate Ag, in comparison with other mucosal immunization routes. Intrarectal immunization induces gut-homing IgA ASCs that localize not only in the colon but also in the small intestine, although they are not responsive to CCL25, unlike IgA ASCs induced by oral immunization.
View Article and Find Full Text PDFMurine norovirus (MNV) was used as a surrogate to study resistance of human norovirus to disinfectants used in hospitals. MNV was sensitive to alcohol, alcohol hand rubs, bleach, and povidone iodine-based disinfectant. Real-time reverse transcription-PCR results indicated that the presence of viral RNA did not correlate with the presence of infectious virus.
View Article and Find Full Text PDFArticle Synopsis
- Rotavirus is a leading cause of severe gastroenteritis in infants, and vaccination through recombinant rotavirus-like particles shows promise for immunity.
- Administering these particles via the intrarectal route with adjuvants like cholera toxin effectively protects adult mice from RV infections and reduces viral shedding compared to intranasal delivery.
- While intranasal vaccination leads to higher IgG and IgA levels in serum, intrarectal immunization results in greater intestinal IgA production, indicating a more robust immune response in the gut.