Publications by authors named "Amanda-Lee Ezra Manicum"
Article Synopsis
- * Nanotechnology offers a promising solution for both early diagnosis and treatment of PCa by enabling precise drug delivery to cancer sites, and it is becoming significant in cancer management.
- * The use of radiolabelled nanomaterials in nuclear medicine aims to enhance the targeting of imaging and treatment agents for PCa, and while there may be safety concerns, their potential to improve patient outcomes looks promising.
Article Synopsis
- - Stigmasterol, an unsaturated phytosterol found in Rhoicissus tridentata, exhibits a range of health benefits including anti-inflammatory, anti-cancer, and neuroprotective properties, making it a valuable compound for pharmacological applications
- - Researchers synthesized eight bio-active derivatives of stigmasterol through various chemical reactions, utilizing spectroscopic methods to confirm their structures and assess their cytotoxicity against specific breast cancer cell lines
- - The synthesized derivatives demonstrated enhanced cytotoxic activity compared to the original stigmasterol, with one derivative (5,6-Epoxystigmast-22-en-3β-ol) particularly showing promising results against the tested cancer cells
Chronic wounds are ubiquitously inhabited by bacteria, and they remain a challenge as they cause significant discomfort and because their treatment consumes huge clinical resources. To reduce the burden that chronic wounds place upon both patients and health services, a wide variety of approaches have been devised and investigated. Bioinspired nanomaterials have shown great success in wound healing when compared to existing approaches, showing better ability to mimic natural extracellular matrix (ECM) components and thus to promote cell adhesion, proliferation, and differentiation.
View Article and Find Full Text PDF, a genus of the Apocynaceae family, consists of evergreen species, such as shrubs as well as small trees that are native to Asia, Africa, and Oceania's subtropical and tropical regions. Most of the species are traditionally used to treat various diseases, such as chest pain, headaches, gonorrhoea, rheumatism, syphilis, oedema, rabies, stomach pain, hepatitis, cardiac diseases, and asthma. The pharmacological studies on species revealed its antioxidant, antimicrobial, anticancer, cardioprotective, antipyretic, analgesic, wound healing, anticonvulsant, antiarthritic, adaptogenic, anti-inflammatory, and antidiabetic activities, thus validating its use in indigenous medicine systems.
View Article and Find Full Text PDFGlobally, cancer is the second (to cardiovascular diseases) leading cause of death. Regardless of various efforts (i.e.
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