Cytogenetic abnormalities, WHO classification, and evolution of children and adolescents with acute myeloid leukemia.

Objectives: To describe cytogenetic and molecular abnormalities observed in children and adolescents with acute myeloid leukemia (AML), classify AML according to the World Health Organization (WHO) classifications from 2008 and 2016, and evaluate the prognosis according to clinical characteristics and cytogenetic abnormalities.

Methods: A retrospective longitudinal study was performed on a population of 98 patients with AML, aged up to 16 years, seen in a single hospital from 2004 to 2015.

Results: Among the 80 patients for whom it was possible to analyze the karyotype, 78.