Publications by authors named "Amanda Winges"
Acute lymphoblastic leukemia (ALL) is currently treated with an intense regimen of chemotherapy yielding cure rates near 85%. However, alterations to treatment strategies using available drugs are unlikely to provide significant improvement in survival or decrease therapy-associated toxicities. Here, we report ectopic expression of the Mer receptor tyrosine kinase in pre-B-cell ALL (B-ALL) cell lines and pediatric patient samples.
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- Metastatic melanoma is highly aggressive and remains difficult to treat despite advances in therapy, with C-MER proto-oncogene tyrosine kinase (MERTK) playing a significant role in disease progression.
- Research shows that MERTK expression is highest in metastatic melanomas compared to primary melanomas and nevi, and its overexpression is frequent in melanoma cell lines without correlating to BRAF or RAS mutations.
- Targeting MERTK with inhibition techniques and specific small-molecule drugs has shown promising results in reducing melanoma cell growth, signaling pathways, and tumor size, highlighting MERTK as a potential therapeutic target.