Publications by authors named "Amanda W Soe"
Article Synopsis
- - The study investigates how G-protein coupled receptors (GPCRs) influence the behavior of pacemaker cardiomyocytes (PCs) in the sinoatrial node (SAN), focusing on those that are differentially expressed compared to right atrial tissue.
- - It specifically explores the cholecystokinin-A receptor (CCKR), finding that it is expressed in mouse PCs and related cells, and reveals that activation of this receptor affects the firing rate of PCs when exposed to its ligand, sulfated cholecystokinin-8 (sCCK-8).
- - The research shows that while the overall function of the SAN isn't severely impacted by losing CCKR, the activation of the chole
Aims: The behavior of pacemaker cardiomyocytes (PCs) in the sinoatrial node (SAN) is modulated by neurohormonal and paracrine factors, many of which signal through G-protein coupled receptors (GPCRs). The aims of the present study are to catalog GPCRs that are differentially expressed in the mammalian SAN and to define the acute physiological consequences of activating the cholecystokinin-A signaling system in isolated PCs.
Methods And Results: Using bulk and single cell RNA sequencing datasets, we identify a set of GPCRs that are differentially expressed between SAN and right atrial tissue, including several whose roles in PCs and in the SAN have not been thoroughly characterized.