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Publications by authors named "Amanda Toledo-Hernandez"

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Pancreatic cancer risk to siblings of probands in bilineal cancer settings.
Kari G Rabe Maria A Stevens Amanda Toledo Hernández Shruti Chandra Joleen M Hubbard

Genet Med

May 2022

Article Synopsis
  • Pancreatic cancer (PC) risk is higher in families where many members have cancer, but it hasn’t been studied much when both parents are sick.
  • The research looked at siblings of people with PC and found that their risk of getting PC increased depending on how many parents had cancer.
  • Siblings with family cancer history felt more worried about developing PC, especially if they had specific gene changes that raised their risk.
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The Period protein homolog LIN-42 regulates germline development in C. elegans.
Skyler Berardi Alanna McFall Amanda Toledo-Hernandez Carolyn Coote Hillary Graham

Mech Dev

October 2018

Germline stem cells are maintained in the distal region of the C. elegans gonad. These cells undergo mitotic divisions, and GLP-1/Notch signaling dictates whether they remain in this state.

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Synopsis of recent research by authors named "Amanda Toledo-Hernandez"

  • - Amanda Toledo-Hernandez's recent research explores the familial risk of pancreatic cancer, notably examining the increased risk for siblings of individuals with pancreatic cancer in bilineal cancer settings, highlighting a need for further inquiry into familial cancer dynamics and risk perception.
  • - The study utilized a prospective registry to analyze cancer triads and estimated standardized incidence ratios (SIRs) to determine the varying risk levels among different familial groupings based on parental cancer history, thus contributing novel insights into hereditary cancer risks.
  • - In addition to cancer risk assessment, Toledo-Hernandez has investigated the role of the Period protein homolog LIN-42 in regulating germline development in C. elegans, providing fundamental understanding of stem cell maintenance and Notch signaling in developmental biology.

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