Publications by authors named "Amanda Tiksnadi"
Article Synopsis
- The study examines how amyloid-beta and tau proteins, which are linked to Alzheimer's disease, affect brain plasticity related to motor functions in individuals with memory issues.
- Twenty-six participants underwent a specific stimulation technique to measure brain responses, alongside tests for cognitive abilities and biomarker levels in cerebrospinal fluid and PET scans.
- Results indicated that this brain stimulation correlated with better cognitive outcomes and lower tau levels, suggesting that monitoring motor-cortical plasticity may help identify Alzheimer's disease earlier than traditional biomarker tests.
Background: Chronic headache is a 'silent' neuropsychiatric systemic lupus erythematosus symptom with heterogeneous prevalence, potentially reaching 54.4%. It may reduce quality of life by increasing the likelihood of depression and sleep disturbance.
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- Quadripulse magnetic stimulation (QPS) is known to change corticospinal excitability, but its long-term depression (LTD) effects often have low success rates; thus, a modified version called paired-associative QPS (PA-QPS) was developed.
- In an experiment, PA-QPS, which pairs electrical stimulation of peripheral nerves with QPS, was found to produce a greater LTD-like effect and had a higher responder rate compared to traditional QPS.
- The findings suggest that PA-QPS could be a more effective option for evaluating and treating neurological disorders due to its strong and consistent effects on corticospinal tract neurons.
Background: Theta burst stimulation (TBS) and quadripulse stimulation (QPS) are known to induce synaptic plasticity in humans. There have been no head-to-head comparisons of the efficacy and variability between TBS and QPS.
Objective: To compare the efficacy and interindividual variability between the original TBS and QPS protocols.
Article Synopsis
- McLeod syndrome is a rare genetic disorder characterized by neurological symptoms like chorea, cognitive issues, and muscle weakness, linked to mutations in the XK gene.
- A 66-year-old man with McLeod syndrome showed significant neurological symptoms, including muscle weakness and gait disturbances, alongside MRI findings of brain atrophy.
- This case represents the first findings indicating central sensorimotor tract involvement specifically in the legs of a McLeod syndrome patient, highlighting the need for further investigation of these pathways despite existing neuropathy symptoms.
Article Synopsis
- Observing mouth movements significantly alters speech perception, leading to the McGurk effect when sounds and lip movements are mismatched.
- Recent studies using fMRI and TMS aimed to understand the motor network’s role in this multisensory illusion, revealing that the left inferior frontal gyrus is crucial in processing incongruent audiovisual information.
- TMS applied to specific lip areas reduced the McGurk effect, indicating that the motor network has a targeted influence on how we integrate visual and auditory speech signals.