Publications by authors named "Amanda T Pettersson-Klein"
Background: Skeletal muscle mass and strength are crucial determinants of health. Muscle mass loss is associated with weakness, fatigue, and insulin resistance. In fact, it is predicted that controlling muscle atrophy can reduce morbidity and mortality associated with diseases such as cancer cachexia and sarcopenia.
View Article and Find Full Text PDFThe role of tryptophan-kynurenine metabolism in psychiatric disease is well established, but remains less explored in peripheral tissues. Exercise training activates kynurenine biotransformation in skeletal muscle, which protects from neuroinflammation and leads to peripheral kynurenic acid accumulation. Here we show that kynurenic acid increases energy utilization by activating G protein-coupled receptor Gpr35, which stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue.
View Article and Find Full Text PDFArticle Synopsis
- Endurance and resistance training lead to significant changes in skeletal muscle genes, particularly involving PGC-1α coactivators, which help the muscles adapt to different exercise types.
- While endurance training primarily boosts PGC-1α1, resistance workouts increase the expression of the less understood PGC-1α2, -α3, and -α4 isoforms, which have distinct functions in muscle adaptation.
- Research reveals that these alternative PGC-1α variants influence gene splicing and regulate various pathways in skeletal muscle, including a reduction in cholesterol synthesis genes, suggesting a complex role in gene expression beyond just endurance and resistance training.