Publications by authors named "Amanda Skillern"
Purpose: To determine the effect of human growth hormone (GH) supplementation during ovarian stimulation in women undergoing IVF/PGT-A cycles, who do not meet the Bologna criteria for poor ovarian response (POR).
Methods: This is a retrospective cohort study of 41 women with suboptimal outcomes in their first cycle of IVF/PGT-A including lower than expected number of MII oocytes, poor blastulation rate, and/or lower than expected number of euploid embryos for their age, who underwent a subsequent IVF/PGT-A cycle with the same fixed dose gonadotropin protocol and adjuvant GH treatment. Daily cotreatment with GH started with first gonadotrophin injection.
Quantitative analysis of tissues and organs can reveal large-scale patterning as well as the impact of perturbations and aging on biological architecture. Here we develop tools for imaging of single cells in intact organs and computational approaches to assess spatial relationships in 3D. In the mouse ovary, we use nuclear volume of the oocyte to read out quiescence or growth of oocyte-somatic cell units known as follicles.
View Article and Find Full Text PDFObjective: To assess oocyte donors' comprehension of the process and potential risks of oocyte donation using the EDICT (Egg Donor Informed Consent Tool).
Design: Prospective cohort study.
Setting: University-based, tertiary reproductive health practice.
Objective: To develop and validate a novel tool to assess the objective and subjective understanding that oocyte donors have of the process and potential risks of oocyte donation.
Design: Prospective cohort study.
Setting: University-based tertiary reproductive health practice.