Paraganglioma of the Right Recurrent Laryngeal Nerve Presenting as a Thyroid Nodule.

Paragangliomas are abnormal growth cells of neuroectodermal origin that arise from the autonomic nervous system. Head and neck paragangliomas are rare, commonly benign and often have a hereditary origin. Head and neck paragangliomas most commonly arise in the carotid bodies, vagus and glossopharyngeal nerves, and the sympathetic chain.

School Bullying and Health Risk Behavior Outcomes among Adolescents in Florida.

This study's purpose is to examine the association between bullying and health-risk behavior outcomes among adolescents in Florida schools. Data were drawn from the 2015 Florida Youth Risk Behavior Survey (YRBS), a school-based survey of high school students from grades 9 to 12 that is conducted biennially. The YRBS estimates six types of health-risk behaviors that contribute to the disability of young youth and the leading causes of morbidity and mortality.

Job Demand-Control and Hypertension in African Americans and Non-African Americans.

Objectives: The aim of this study was to determine if occupational stress is a social determinant of elevated hypertension among African Americans.

Methods: Currently employed, full-time adults from the Midlife in the United States Refresher and Midlife in the United States Milwaukee Refresher studies reported data on demographics, job characteristics, and medical history.

Results: African American workers reported less job control and greater physical job demands than non-African Americans.

Efficacy and tolerability of stereotactic body radiotherapy for lung metastases in three patients with pediatric malignancies.

To report a case series of 3 pediatric patients treated with Stereotactic Body Radiation Therapy (SBRT) for lung metastases. Three patients (ages 9, 11, and 21) received SBRT for rhabdoid tumor, Ewing sarcoma, and Wilms tumor histologies, respectively. SBRT doses were 37.

Melanoma Outcomes in Transplant Recipients With Pretransplant Melanoma.

Background: There are limited data on outcomes in transplant recipients with a history of pretransplant melanoma.

Objective: To determine whether pretransplant melanoma is associated with differences in survival or posttransplant melanoma risk.

Materials And Methods: We evaluated the outcomes of 185,039 US transplant recipients from the Transplant Cancer Match Study.

Patterns of recurrence following complete response to regional chemotherapy for in-transit melanoma.

Background: Even after complete response (CR) to regional chemotherapy for in-transit melanoma, many patients develop recurrence. Understanding the probability, location, and timing of recurrences can optimize management strategies for this patient population.

Methods: A prospective database identified patients who underwent 81 first-time hyperthermic isolated limb perfusions (HILPs) and 133 first-time isolated limb infusions (ILIs).

Current trends in regional therapy for melanoma: lessons learned from 225 regional chemotherapy treatments between 1995 and 2010 at a single institution.

Background: Hyperthermic isolated limb perfusion (HILP) and isolated limb infusion (ILI) are used to manage advanced extremity melanoma, but no consensus exists as to which treatment is preferable and how to monitor patients post-treatment.

Study Design: Using a prospectively maintained database, we reviewed our experience with melphalan-based HILP (which included 62 first-time and 10 second-time) and ILI (which included 126 first-time and 18 second-time) procedures performed in 188 patients. PET/CT was obtained 3 months postregional treatment for 1 year and then every 6 months thereafter.

A two-hybrid assay to study protein interactions within the secretory pathway.

Interactions of transcriptional activators are difficult to study using transcription-based two-hybrid assays due to potent activation resulting in false positives. Here we report the development of the Golgi two-hybrid (G2H), a method that interrogates protein interactions within the Golgi, where transcriptional activators can be assayed with negligible background. The G2H relies on cell surface glycosylation to report extracellularly on protein-protein interactions occurring within the secretory pathway.

Regional treatment strategies for in-transit melanoma metastasis.

For in-transit melanoma confined to the extremities, regional chemotherapy in the form of hyperthermic isolated limb perfusion and isolated limb infusion are effective treatment modalities carrying superior response rates to current standard systemic therapy. Despite high response rates, most patients will eventually recur, supporting the role for novel research aimed at improving durable responses and minimizing toxicity. Although the standard cytotoxic agent for regional chemotherapy is melphalan, alternative agents such as temozolomide are currently being tested, with promising preliminary results.

Neurogenesis of oxytocin-containing neurons in the paraventricular nucleus (PVN) of the female pig in 3 reproductive states: puberty gilts, adult gilts and lactating sows.

Evidence suggests that neurogenesis occurs in the adult hypothalamus, including centers containing oxytocin and vasopressin producing neurons. The present study was undertaken to look at one of these centers, the paraventricular nucleus (PVN), to describe its morphology, confirm the presence of neurogenesis and examine the effect of reproductive status on the incidence of neurogenesis. Serial sections of the paraffin-embedded hypothalamus were made from five puberty gilts, four adult gilts and four lactating sows.