Publications by authors named "Amanda Ramilo Amor"
Article Synopsis
- - A significant challenge in treating pediatric T-cell acute lymphoblastic leukemia is predicting and tackling leukemia relapse in the central nervous system (CNS), where leukemia cells can hide and resist treatment.
- - Researchers found that intrusive leukemia cells change gene expression patterns, leading to enhanced cell survival, resistance to chemotherapy, and faster disease progression when infiltrating the CNS.
- - The study revealed that leukemia cells interact with human meningeal cells, causing epigenetic changes that might serve as potential biomarkers to identify CNS involvement and relapse in leukemia patients.
With modern treatment most children with acute lymphoblastic leukemia (ALL) survive without relapse. However, for children who relapse the prognosis is still poor, especially in children with T-cell phenotype (T-ALL) and remains the major cause of death. The exact mechanism of relapse is currently not known.
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