Publications by authors named "Amanda P de Oliveira"
Article Synopsis
- The study aimed to review how different Artificial Intelligence algorithms perform in validating mammography for breast cancer screening through a systematic analysis of existing research.
- After searching major medical databases and filtering through thousands of articles, 30 relevant studies were selected for analysis over the past decade.
- The findings indicated that AI algorithms can match radiologists in accuracy and even improve mammogram evaluations when used alongside them, aiding both experienced and less experienced medical professionals in detecting potential lesions.
Article Synopsis
- CCR5 is a chemokine receptor linked to immune responses against infections, and this study investigates its association with ocular toxoplasmosis using two genetic polymorphisms (CCR5Δ32 and CCR5 59029 A/G).
- The study involved 480 patients divided into three groups based on the presence of ocular toxoplasmosis, and the analysis revealed significant age differences among these groups.
- Results indicated that individuals with both the CCR5/CCR5 genotype and CCR5-59029 AA or AG genotypes have a higher risk (4% more) of developing ocular toxoplasmosis, suggesting a link to a strong inflammatory response in the eyes.
Article Synopsis
- - The study examined plasma levels of the chemokines CCL3 and CCL4 in patients with different clinical forms of chronic Chagas disease, focusing on those with and without left ventricular systolic dysfunction (LVSD).
- - It involved analyzing plasma samples from 75 patients using ELISA and Milliplex® MAP assay, confirming the T. cruzi infection.
- - Results showed no significant level differences of CCL3 and CCL4 between digestive and cardiac forms of Chagas disease, and found that while LVSD patients had higher chemokine levels, CCL3 and CCL4 do not seem to affect susceptibility to the disease forms or influence LVSD development.
Article Synopsis
- - Chagas disease, caused by the parasite Trypanosoma cruzi, can lead to various health issues like heart problems and digestive tract complications, but the factors determining why some people are symptomatic and others are not remain unclear.
- - This study involved 339 adults with chronic Chagas disease and aimed to explore how different blood group systems (ABO, Secretor, and Lewis) might be linked to the disease’s clinical forms.
- - While no significant differences were found between patients and healthy controls for the blood group systems, the combination of B plus AB Secretor phenotypes was significantly more common in patients with megacolon and megaesophagus compared to those with A plus O Secretor phenotypes.
Article Synopsis
- - Chagas disease, caused by the protozoan Trypanosoma cruzi, can present in various chronic forms like indeterminate, cardiac, or digestive, influenced by genetic variability in both the parasite and the host.
- - The immune response is regulated by cytokines and chemokines, which are crucial for controlling leukocyte migration and can lead to inflammation and tissue damage during infections.
- - The study specifically focuses on the CC Chemokine Receptor 5 (CCR5) and its role in the migration of immune cells during T. cruzi infection, highlighting its significance in the disease's pathogenesis.
The clinical manifestations of chronic Chagas disease include the cardiac form of the disease and the digestive form. Not all the factors that act in the variable clinical course of this disease are known. This study investigated whether the CCR5Δ32 (rs333) and CCR5 59029 A/G (promoter region--rs1799987) polymorphisms of the CCR5 gene are associated with different clinical forms of chronic Chagas disease and with the severity of left ventricular systolic dysfunction in patients with chronic Chagas heart disease (CCHD).
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