SV40 infection associated with rituximab treatment after kidney transplantation in nonhuman primates.

Background: A regimen consisting of polyclonal anti-T-cell antibody, sirolimus (SRL), and donor bone marrow (DBM) infusion induces robust transplantation tolerance to skin allografts in mice. We investigated the effect of a similar regimen in a nonhuman primate (NHP) model.

Methods: Cynomolgus macaques (Macaca fascicularis) were transplanted with mismatched kidney allografts.