Publications by authors named "Amanda Macamo"
Article Synopsis
- - Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with increasing rates in the US and Europe, primarily linked to the Merkel cell polyomavirus (MCPyV), although its cell of origin is still uncertain.
- - The study introduced MCPyV antigens into different cancer cell lines to analyze how they affect DNA methylation and gene expression, revealing that MCPyV-LT alters DNA methylation in both cell lines while MCPyV-sT only impacted one.
- - Findings indicate significant changes in gene expression patterns, particularly in MCC13 cells, with downregulated genes in immune pathways suggesting potential targets for new immunotherapies for MCC, along with confirmation that MCPyV-LT regulates gene
