Publications by authors named "Amanda M Cornelison"
Cardiac involvement in systemic light chain amyloidosis (AL) is generally associated with a worse outcome, especially if other organs are also involved. We sought to determine whether concurrent cardiac and renal involvement were associated with a worse outcome than either organ alone. We identified 129 patients with AL, who received high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HCT) at our institution between 1997 and 2014.
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- High-risk multiple myeloma patients show poor clinical outcomes compared to standard-risk patients, as identified through cytogenetic and FISH testing.
- A study of 670 myeloma patients revealed that 11% were classified as high-risk, displaying lower response rates and significantly shorter progression-free and overall survival times after undergoing autologous stem-cell transplantation.
- The presence of multiple high-risk cytogenetic abnormalities correlates with worse survival, emphasizing the need for tailored treatment strategies for these patients despite advancements in therapies.