Adaptor protein complex-4 (AP-4) deficiency causes a novel autosomal recessive cerebral palsy syndrome with microcephaly and intellectual disability.

Background: Cerebral palsy is a heterogeneous group of neurodevelopmental brain disorders resulting in motor and posture impairments often associated with cognitive, sensorial, and behavioural disturbances. Hypoxic-ischaemic injury, long considered the most frequent causative factor, accounts for fewer than 10% of cases, whereas a growing body of evidence suggests that diverse genetic abnormalities likely play a major role.

Methods And Results: This report describes an autosomal recessive form of spastic tetraplegic cerebral palsy with profound intellectual disability, microcephaly, epilepsy and white matter loss in a consanguineous family resulting from a homozygous deletion involving AP4E1, one of the four subunits of the adaptor protein complex-4 (AP-4), identified by chromosomal microarray analysis.

A confirmatory factor analysis of the Boredom Proneness Scale.

Researchers have extensively investigated the factor structure of the Boredom Proneness Scale (BPS; R. Farmer & N. D.

On the relationship between meaning in life and boredom proneness: examining a logotherapy postulate.

Logotherapy, developed by Viktor Frankl, posits that when one lacks meaning in life, boredom can result. Thus, the two constructs should be inversely related. To examine this relationship, 279 students (M = 19.

Confirmatory factor analysis of the Computer Understanding and Experience Scale.

The two-factor structure (Technical Competence, General Competence) of the Computer Understanding and Experience Scale was examined through confirmatory factor analysis with a sample of 293 undergraduates from a medium-sized university located in the southern USA. Analysis indicated that the two-factor subscale structure of the Computer Understanding and Experience Scale was supported. The Computer Understanding and Experience Scale's total score is internally consistent (.