Publications by authors named "Amanda Lima Oliveira"
Our research group previously studied the effectiveness of lipid-core nanocapsules (LNC) containing simvastatin (SV-LNC) in treating cognitive impairment in rats. While our results were promising, we needed to evaluate the potential toxicity of the nanoparticles themselves. This study aimed to compare the biochemical and hematological parameters of adult Wistar rats receiving LNC or SV-LNC to those receiving low doses of simvastatin crystals dispersed in a saline solution over 45 days.
View Article and Find Full Text PDFLipid-core nanocapsules containing simvastatin improve the cognitive impairment induced by obesity and hypercholesterolemia in adult rats.
Eur J Pharm Sci
August 2020
The development of cognitive impairment may be related to high levels of plasma cholesterol and obesity. Simvastatin (SV) and lovastatin (LV) are drugs that can potentially be used for the treatment of cognitive deficit. This study aimed to develop and characterize lipid-core nanocapsules (LNC) containing SV (SV-LNC) or LV (LV-LNC), evaluating the effects of SV-LNC in an animal model of cognitive deficit.
View Article and Find Full Text PDFImplementation of the trauma registry as a tool for quality improvement in trauma care in a brazilian hospital: the first 12 months.
Rev Col Bras Cir
August 2017
Article Synopsis
- The study evaluates the implementation of a trauma registry at a university teaching hospital under Brazil's SUS, aiming to enhance care quality for trauma patients.
- Data was collected by medical and nursing students using the itreg database, which included 1344 trauma cases from 2014, primarily blunt traumas.
- Key issues identified for improvement include managing patient overtriage, reducing unnecessary imaging, and establishing protocols for central venous access and traumatic brain injury management.
Objective: to verify the effectiveness of coconut water in preserving tissues for transplant.
Methods: Fifty male Wistar rats were randomly distributed in five groups, according to the following preservation solutions for tissue grafts: Group 1: Lactated Ringer; Group 2: Belzer solution; Group 3: mature coconut water; Group 4: green coconut water; Group 5: modified coconut water. In Group 5, the green coconut water has been modified like the Belzer solution.