Comparative effectiveness and safety of BNT162b2 and CoronaVac in Hong Kong: A target trial emulation.

Objectives: To evaluate the difference between BNT162b2 and CoronaVac in vaccine effectiveness and safety.

Methods: This target trial emulation study included individuals aged ≥12 during 2022. Propensity score matching was applied to ensure group balance.

Benefits and Risks Associated With Statin Therapy for Primary Prevention in Old and Very Old Adults : Real-World Evidence From a Target Trial Emulation Study.

Background: There is little consensus on using statins for primary prevention of cardiovascular diseases (CVDs) and all-cause mortality in adults aged 75 years or older due to the underrepresentation of this population in randomized controlled trials.

Objective: To investigate the benefits and risks of using statins for primary prevention in old (aged 75 to 84 years) and very old (aged ≥85 years) adults.

Design: Sequential target trial emulation comparing matched cohorts initiating versus not initiating statin therapy.