Beneficial Effects of Guided Imagery or Clinical Massage on the Status of Patients in a Progressive Care Unit.

Background: Patients in the progressive care unit typically experience high levels of pain and anxiety and exhibit difficulty sleeping.

Objective: To determine whether either clinical massage or guided imagery could reduce pain and anxiety and improve sleep.

Methods: This study included 288 inpatients on 2 floors of a progressive care unit.

Identification of tumor and invasion suppressor gene modulators in bladder cancer by different classes of histone deacetylase inhibitors using reverse phase protein arrays.

Purpose: We assessed the ability of different classes of histone deacetylase inhibitors to target tumor and invasive suppressor genes in a panel of bladder carcinoma cell lines using reverse phase protein arrays.

Materials And Methods: Three poorly, moderately and highly invasive cell lines were exposed to histone deacetylase inhibitors, trichostatin A, apicidin, valproic acid (Sigma) and MS-275 (AXXORA) for 0 to 36 hours. Lysates were harvested and arrayed in a 10-fold dilution series in duplicate.

A MicroRNA expression profile defining the invasive bladder tumor phenotype.

Objective: The purpose of this study was to identify microRNA (miRNA) involved in the transition between the noninvasive and invasive urothelial carcinoma of the bladder (UCB) phenotype.

Methods: Differential expression of miRNA was identified in a microarray format between noninvasive and invasive UCB cell lines and confirmed using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) within this cell panel. Normalization of qRT-PCR with miR-222 was established from the microarray data and validated within a panel of 57 UCB tumors (26 noninvasive lesions (Ta/G1) and 31 invasive lesions (T2-T4).