Prospective observational multi-poison center study of ziprasidone exposures.

Background: Ziprasidone is an atypical antipsychotic associated with QTc prolongation during therapeutic use. We characterized the clinical manifestations associated with ziprasidone overdoses, in particular the incidence and severity of QTc prolongation.

Methods: Four regional poison centers prospectively collected ziprasidone overdose data from August 1, 2003 to October 1, 2005.

Atypical experience: a case series of pediatric aripiprazole exposures.

Background: Aripiprazole is a new psychotropic agent that possesses a unique pharmacologic profile. The drug demonstrates mixed dopamine and serotonin agonist-antagonist activity and has been labeled a third-generation antipsychotic and dopamine-serotonin system stabilizer. Overdose experience is limited, especially in pediatrics.

Evaluation of lamotrigine toxicity reported to poison centers.

Background: Lamotrigine is an antiepileptic drug for the treatment of partial and generalized seizures as well as bipolar disorder. Limited published information exists describing the clinical effects of lamotrigine overdose.

Objective: To examine the toxicity of exposures to lamotrigine utilizing national poison center data.