Publications by authors named "Amanda L Dobbyn"
Article Synopsis
- Bipolar disorder has a genetic basis and complex causes; a large study compared nearly 42,000 bipolar patients with over 371,000 healthy controls, revealing 64 genomic regions linked to the disorder.
- The findings showed that risk-related genes are heavily associated with brain functions, particularly in areas like the prefrontal cortex and hippocampus, and they include targets for various medications.
- The research also distinguished between bipolar disorder types I and II, revealing a close genetic relationship and highlighting 15 specific genes that could lead to new treatment options and further investigations.
Article Synopsis
- * The analysis discovered 30 significant genetic loci linked to bipolar disorder, including 20 that hadn't been previously identified, which involve genes related to ion channels and neurotransmitter systems.
- * The study also showed that Bipolar I disorder has a genetic connection to schizophrenia, particularly linked to psychosis, while Bipolar II disorder is more closely related to major depressive disorder, shedding light on potential biological mechanisms and clinical implications.
