Gut microbiome differences among Mexican Americans with and without type 2 diabetes mellitus.

Purpose: Type 2 diabetes mellitus (T2DM) is an urgent public health problem and disproportionately affects Mexican Americans. The gut microbiome contributes to the pathophysiology of diabetes; however, no studies have examined this association in Mexican-Americans. The objective of this study was to compare gut microbiome composition between Mexican-Americans with and without T2DM.

National ambulatory care non-insulin antidiabetic medication prescribing trends in the United States from 2009 to 2015.

Objective: Despite their efficacy in lowering hemoglobin A1c, recent data suggest that sulfonylureas are associated with cardiovascular risk and hypoglycemia. The objective of this study was to determine whether prescribers decreased sulfonylurea use in favor of newer medications in the United States over seven years.

Research Design And Methods: This cross-sectional study utilized data from the Centers for Disease Control and Prevention's National Ambulatory Medical Care Survey.

Pimavanserin: A Novel Drug Approved to Treat Parkinson's Disease Psychosis.

: Pimavanserin is the first United States Food and Drug Administration (FDA)-approved treatment for Parkinson's disease psychosis (PDP). This article reviews the safety, efficacy, and pharmacology data for pimavanserin and its role in therapy. Initial literature sources were identified via MEDLINE search (1946-September 2016) of pimavanserin and ACP-103 (original molecular designation).