Publications by authors named "Amanda Jacobson-Kelly"
Article Synopsis
- * In 2023, the Pediatric ITP Consortium defined refractory pediatric ITP as no platelet response after treatment with all eligible emergent therapies.
- * Patients with high disease burden or lack of platelet response, despite various treatments, are identified as a challenging group that requires further research and the potential for new treatment options.
Hemarthrosis in a Pediatric Patient With Immune Thrombocytopenia and Lyme Arthritis.
J Pediatr Hematol Oncol
January 2024
The presentation of immune thrombocytopenia is dependent on the degree of thrombocytopenia, with no to mild bleeding symptoms, primarily mucocutaneous bleeding. Severe bleeding in other organ systems is a rare complication. Spontaneous hemarthrosis is rare in patients without hemophilia.
View Article and Find Full Text PDFDiagnosis and Treatment of Iron Deficiency and Anemia in Youth With Inflammatory Bowel Disease.
J Pediatr Gastroenterol Nutr
March 2023
Objectives: Iron deficiency (ID) with and without anemia is prevalent in children and adults diagnosed with inflammatory bowel disease (IBD), but often goes unrecognized. We hypothesized, quality improvement (QI) methodology could increase the screening for and treatment of ID in children newly diagnosed with IBD.
Methods: We developed and implemented an easy-to-follow algorithm to facilitate screening for and treatment of ID for patients diagnosed with IBD.
Somatic variation as an incidental finding in the pediatric next-generation sequencing era.
Cold Spring Harb Mol Case Stud
December 2021
Article Synopsis
- Next-generation sequencing (NGS) enables detailed genomic analysis, but can also uncover incidental findings that complicate interpretation, especially in children.
- A case study of a 16-month-old boy with developmental delays identified two genetic variants through clinical exome sequencing: one linked to intellectual disability and another associated with a childhood cancer syndrome.
- The study emphasizes the importance of thoroughly analyzing different tissue samples and understanding the implications of incidental genetic findings in pediatric care.
Abnormal uterine bleeding in users of rivaroxaban and apixaban.
Hematology Am Soc Hematol Educ Program
December 2020
Up to two-thirds of menstruating women experience abnormal uterine bleeding (AUB) when treated with oral anticoagulants. However, the true prevalence of AUB for specific agents remains uncertain, as many of these episodes, while interfering significantly with quality of life and overall health, are not captured by definitions of major bleeding (MB) or clinically relevant nonmajor bleeding (CRNMB) used in clinical trials. A 2017 systematic review determined that women taking rivaroxaban, but not edoxaban or apixaban, had a twofold higher risk of AUB than women taking warfarin.
View Article and Find Full Text PDFObjective: To evaluate trends in diagnosis and management of iron deficiency anemia using a large national children's hospital database in pediatric patients admitted with inflammatory bowel disease (IBD).
Study Design: In this retrospective multicenter cohort study, we used the Pediatric Health Information System de-identified administrative database. Patients age <21 years with ≥2 admissions with International Classification of Disease, Ninth Revision and Tenth Revision codes for Crohn's disease or ulcerative colitis from 2012 to 2018 were included.