Publications by authors named "Amanda Holsworth"
Newborn tandem mass spectroscopy screening for adenosine deaminase deficiency.
Ann Allergy Asthma Immunol
December 2022
Background: Newborn screening (NBS) by means of T cell receptor excision circles (TREC) is now universal in the United States, Puerto Rico, and the Navajo Nation as a strategy to identify severe combined immunodeficiency (SCID) in newborns. Owing to the characteristics of adenosine deaminase (ADA) deficiency, a small but important number of cases can be missed by this screening.
Objective: To evaluate the results of the first year statewide NBS for ADA by means of dried blood spot NBS.
Article Synopsis
- The study investigates the varying immune responses in hospitalized COVID-19 patients by analyzing blood RNA, aiming to understand how these differences affect clinical outcomes.
- Researchers enrolled 36 COVID-19 patients and 15 controls, utilizing advanced RNA sequencing techniques, revealing significant changes in 770 genes linked to immune responses and viral defense.
- Findings highlight that therapies like convalescent serum and dexamethasone can alter gene expression associated with COVID-19, and severe cases exhibit unique gene patterns indicating secondary infections and immune dysregulation.
A single-center experience of treating 19 patients with chronic cold urticaria.
J Allergy Clin Immunol Pract
November 2021