Synopsis of recent research by authors named "Amanda G Nichols"
- Amanda G. Nichols' recent research focuses on the interactions between metabolic hormones, such as insulin, IGF-1, and leptin, and their effects on T cell metabolism and immune function, particularly in the context of obesity and associated inflammatory responses.
- Her studies reveal distinct roles of insulin and IGF-1 on CD4 T cells, highlighting that IGF-1R expression increases during T cell activation, and that leptin signaling enhances the function of inflammatory T helper cells, contributing to systemic glucose intolerance in obesity.
- Additionally, Nichols investigates the metabolic alterations in T cells due to obesity, demonstrating that these changes impair memory T cell responses to influenza and suggesting that altered metabolism impacts immune functionality significantly.
