Publications by authors named "Amanda E Liefeld"
Proc Natl Acad Sci U S A
July 2021
Article Synopsis
- Opportunistic pathogens form antibiotic-resistant biofilms that complicate infections in immunocompromised individuals, and the study highlights the role of small RNAs in this process.
- The research shows that microRNA let-7b-5p, found in extracellular vesicles secreted by human airway epithelial cells, can inhibit key proteins that promote biofilm formation and enhance susceptibility to beta-lactam antibiotics.
- The transfer of miRNAs from human cells to bacteria demonstrates a novel method of communication that could be leveraged in treatment strategies for chronic lung infections related to antibiotic resistance.
