Publications by authors named "Amanda E Jimenez"
Article Synopsis
- The BCG vaccine strain is being used to create stable recombinant vaccines expressing HIV and SIV antigens, which is significant due to its established safety profile.
- A method involving leucine auxotrophic complementation was developed to ensure the consistent expression and stability of these recombinant strains.
- Quality control measures confirmed the stability and efficiency of antigen production, leading to successful immune responses in mice, thus increasing confidence in the vaccine's potential for use in immunogenicity studies.
PRP19 is a ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR). Although the role for PRP19 in splicing is well characterized, its role in the DDR remains elusive. Through a proteomic screen for proteins that interact with RPA-coated single-stranded DNA (RPA-ssDNA), we identified PRP19 as a sensor of DNA damage.
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