Unveiling novel insights: geraniol's enhanced anti-candida efficacy and mechanistic innovations against multidrug-resistant candida strains.

Objectives: This study addressed the need for new treatments for severe Candida infections, especially resistant strains. It evaluated the antifungal potential of geraniol alone and with fluconazole against various Candida spp., including resistant strains, and investigated geraniol's mechanism of action using flow cytometry.

Evaluation of amlodipine against strains of spp. in planktonic cells, developing biofilms and mature biofilms.

To evaluate the antifungal activity of amlodipine against strains of spp. and to its possible mechanism of action. Broth microdilution tests were used to determine the minimum inhibitory concentration, while the synergistic activity was evaluated by calculating the fractional inhibitory concentration index.

Antifungal activity of tannic acid against Candida spp. and its mechanism of action.

The increase in fungal resistance is a major public health concern. In this context, Candida spp. is an important genus related to invasive diseases, especially in immunosuppressed patients.

Anticandidal activity of Kunth essential oil is enhanced by N-acetylcysteine and itraconazole.

Evaluate the anticandidal effect of Kunth essential oil and its interaction with azoles and N-acetylcysteine (NAC) against planktonic cells and biofilms. Broth microdilution and checkerboard methods were used to evaluate the individual and combined activity with fluconazole and itraconazole (ITRA). The antibiofilm effect of the oil was assessed in 96-well plates alone and combined with ITRA and NAC, and cytotoxicity determined by MTT.

Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant spp.

To evaluate the antifungal activity of mangiferin against spp. resistant to fluconazole. The antifungal activity of mangiferin was assessed using broth microdilution and its interaction with azoles and amphotericin B was evaluated by checkerboard.

Antifungal activity of propafenone on spp. strains: interaction with antifungals and possible mechanism of action.

The development of new antifungal drugs has become a global priority, given the increasing cases of fungal diseases together with the rising resistance to available antifungal drugs. In this scenario, drug repositioning has emerged as an alternative for such development, with advantages such as reduced research time and costs. Propafenone is an antiarrhythmic drug whose antifungal activity is poorly described, being a good candidate for further study.

Antibiofilm activity of promethazine against ESBL-producing strains of Escherichia coli in urinary catheters.

The bacterium Escherichia coli is one of the main causes of urinary tract infections. The formation of bacterial biofilms, especially associated with the use of urinary catheters, contributes to the establishment of recurrent infections and the development of resistance to treatment. Strains of E.

Promising activity of etomidate against mixed biofilms of fluconazole-resistant and methicillin-resistant .

and are recognized for their development of resistance and biofilm formation. New therapeutic alternatives are necessary in this context. Etomidate shows potential application in catheters against mixed biofilms of fluconazole-resistant and methicillin-resistant (MRSA).

Antimicrobial activity of hydralazine against methicillin-resistant and methicillin-susceptible .

is a human pathogen responsible for high mortality rates. The development of new antimicrobials is urgent. The authors evaluated the activity of hydralazine along with its synergism with other drugs and action on biofilms.

Analysis of possible pathways on the mechanism of action of minocycline and doxycycline against strains of spp. resistant to fluconazole.

Species of the genus characterized as commensals of the human microbiota, are opportunistic pathogens capable of generating various types of infections with high associated costs. Considering the limited pharmacological arsenal and the emergence of antifungal-resistant strains, the repositioning of drugs is a strategy used to search for new therapeutic alternatives, in which minocycline and doxycycline have been evaluated as potential candidates. Thus, the objective was to evaluate the antifungal activity of two tetracyclines, minocycline and doxycycline, and their possible mechanism of action against fluconazole-resistant strains of spp.

Antibacterial activity of menadione alone and in combination with oxacillin against methicillin-resistant and its impact on biofilms.

Antibiotic resistance is a major threat to public health, particularly with methicillin-resistant (MRSA) being a leading cause of antimicrobial resistance. To combat this problem, drug repurposing offers a promising solution for the discovery of new antibacterial agents. Menadione exhibits antibacterial activity against methicillin-sensitive and methicillin-resistant strains, both alone and in combination with oxacillin.

Antifungal activity of selective serotonin reuptake inhibitors against Cryptococcus spp. and their possible mechanism of action.

Fungal infections caused by Cryptococcus spp. pose a threat to health, especially in immunocompromised individuals. The available arsenal of drugs against cryptococcosis is limited, due to their toxicity and/or lack of accessibility in low-income countries, requiring more therapeutic alternatives.

Sertraline has activity against both mature and forming biofilms of different species.

spp. infections are a serious health problem, especially in patients with risk factors. The acquisition of resistance, often associated with biofilm production, makes treatment more difficult due to the reduced effectiveness of available antifungals.

Antifungal activity of etomidate against growing biofilms of fluconazole-resistant spp. strains, binding to mannoproteins and molecular docking with the ALS3 protein.

This study evaluated the effect of etomidate against biofilms of spp. and analysed through molecular docking the interaction of this drug with ALS3, an important protein for fungal adhesion. Three fluconazole-resistant fungi were used: , and .