Prospective Study of Clinical Outcomes From a Breast Implant Assessment Service.

Background: Breast augmentation remains the commonest cosmetic surgical procedure worldwide, in spite of recent regulatory action.

Objectives: The aim of this study was to evaluate women with breast implants attending a breast implant assessment clinic and to capture clinical and implant data in women presenting to the service.

Methods: Patients were enrolled prospectively between January 2018 and December 2021.

Breast implants: A guide for general practice.

Background: Silicone breast implants have been used for post-mastectomy breast reconstruction and cosmetic augmentation since the 1960s. Recent regulatory action has resulted in a few devices being suspended or cancelled from the Australian market.

Objective: The aim of this article is to summarise important clinical information on how best to assess women with breast implants, and recognise and manage adverse events related to these devices.

The "Game of Implants": A Perspective on the Crisis-Prone History of Breast Implants.

Since their introduction into the market, breast implants have been the subject of many controversies. It is timely to examine the forces that have shaped the breast implant industry to make it what it is today. This review will concentrate more on the use of implants in aesthetic surgery rather than their use in breast reconstruction, but some of the factors have relevance to both indications.

Coming to terms with the fact that the evidence for laparoscopic entry is as good as it gets.

Entry to the peritoneal cavity for laparoscopic surgery is associated with defined morbidity, with all entry techniques associated with substantial complications. Debate over the safest entry technique has raged over the last 2 decades, and yet, we are no closer to arriving at a scientifically valid conclusion regarding technique superiority. With hundreds of thousands of patients required to perform adequately powered studies, it is unlikely that appropriately powered comparative studies could be undertaken.

BAFF, APRIL and human B cell disorders.

B cells require signals from multiple sources for their development from precursor cells, and differentiation into effector cells. BAFF has been identified as a critical regulator of B cell development and differentiation. Defects in the production of BAFF and/or expression of its receptors have been associated with a diverse array of human immunopathologies characterised by perturbed B cell function and behaviour, including autoimmunity, malignancy, and immunodeficiency.

Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity.

X-linked lymphoproliferative disease (XLP) is a severe immunodeficiency associated with a marked reduction in circulating memory B cells. Our investigation of the B cell compartment of XLP patients revealed an increase in the frequency of a population of B cells distinct from those previously defined. This population displayed increased expression of CD10, CD24, and CD38, indicating that it could consist of circulating immature/transitional B cells.