Publications by authors named "Amanda Cao"

Article Synopsis
  • Pompe disease is a rare genetic disorder caused by a deficiency in acid alpha-glucosidase, leading to muscle weakness and other symptoms, often neglecting pain and psychological aspects.
  • A case study discusses a child with late-onset Pompe disease who experiences chronic pain, diagnosed at 9 years old after various initial misattributions.
  • Treatment includes enzyme replacement therapy and a multidisciplinary approach focusing on physical and psychosocial therapies to manage pain and improve the child's overall well-being.
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Article Synopsis
  • Niemann-Pick disease type C (NPC) is a rare genetic disorder that leads to the buildup of cholesterol and lipids in cells, causing various neurological and systemic issues, affecting both patients and their caregivers over time.
  • *Focus group discussions with 19 individuals, including both patients and caregivers, identified key concerns such as cognitive decline, motor function impairment, loss of independence, and social isolation.
  • *The feedback from these discussions also highlighted challenges related to participating in research, particularly logistical issues around travel and the need for sedation during MRI scans, while offering insights for future studies on NPC.
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Objective: To measure racial and gender differences in medical student burnout and identify possible contributing factors.

Patients And Methods: Electronic surveys were distributed to medical students at 9 US medical schools from December 27, 2020, through January 17, 2021. Questions covered demographic characteristics, stressors contributing to burnout, and the 2-item Maslach Burnout Inventory.

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Background: This study aimed to identify differences in patient characteristics, perioperative management methods, and outcomes for total hip arthroplasty (THA) for femoral neck fracture (FNF) when performed by orthopaedic surgeons who have arthroplasty versus orthopaedic trauma training.

Methods: This study was a multicenter retrospective review of 636 patients who underwent THA for FNF between 2010 and 2019. There were 373 patients who underwent THA by an arthroplasty surgeon, and 263 who underwent THA by an orthopaedic trauma surgeon.

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Multiple myeloma is an incurable plasma cell malignancy with only a 53% 5-year survival rate. There is a critical need to find new multiple myeloma vulnerabilities and therapeutic avenues. Herein, we identified and explored a novel multiple myeloma target: the fatty acid binding protein (FABP) family.

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Unlabelled: Multiple myeloma (MM) develops from well-defined precursor stages; however, invasive bone marrow (BM) biopsy limits screening and monitoring strategies for patients. We enumerated circulating tumor cells (CTC) from 261 patients (84 monoclonal gammopathy of undetermined significance, 155 smoldering multiple myeloma, and 22 MM), with neoplastic cells detected in 84%. We developed a novel approach, MinimuMM-seq, which enables the detection of translocations and copy-number abnormalities through whole-genome sequencing of highly pure CTCs.

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Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting.

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Elderly people often suffer adverse health because of inflammation associated with poor metabolism and cardiovascular dysfunction, but these conditions present differently in men and women. We performed experiments in aged male and female mice to understand this sexual dimorphism. We focused on sphingosine 1-phosphate (S1P) signaling, which has both protective and detrimental effects on vascular and metabolic function.

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