Synopsis of recent research by authors named "Amanda C Weiss"
- Amanda C Weiss's research focuses on the interplay between neuronal activity and the secretion of biologically active molecules from skeletal muscle, highlighting the significance of myokines and exosomes in brain homeostasis, particularly in the context of neuromuscular diseases.
- In her study on hippocampal neurons, she investigates homeostatic plasticity mechanisms, revealing how prolonged activity blockade influences potassium channel gene expression and action potential firing rates, emphasizing the adaptability of neuronal networks to changing conditions.
- Weiss also explores the effects of prolonged seizure activity on potassium channels, demonstrating that caspase-dependent cleavage of GIRK subunits is linked to seizure-induced hippocampal atrophy, underscoring the impact of excitotoxicity on neuronal function.
