Publications by authors named "Amanda C Franklin"
Article Synopsis
- Acoustic patterning with ultrasound standing waves offers a promising biotechnology for creating organized cell systems, useful for developing organoid cultures and complex tissues.
- However, challenges like cell array uniformity and disruption factors remain, with no thorough assessment of acoustically-patterned cell quality conducted until now.
- This study introduces Voronoï tessellation to create metrics for evaluating the impact of various parameters on cell patterns, aiming to enhance quality control and process tracking in acoustic patterning.
Tissue engineering has offered unique opportunities for disease modeling and regenerative medicine; however, the success of these strategies is dependent on faithful reproduction of native cellular organization. Here, it is reported that ultrasound standing waves can be used to organize myoblast populations in material systems for the engineering of aligned muscle tissue constructs. Patterned muscle engineered using type I collagen hydrogels exhibits significant anisotropy in tensile strength, and under mechanical constraint, produced microscale alignment on a cell and fiber level.
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