Cardiac Chagas Disease: MMPs, TIMPs, Galectins, and TGF- as Tissue Remodelling Players.

A century after the discovery of Chagas disease, studies are still needed to establish the complex pathophysiology of this disease. However, it is known that several proteins and molecules are related to the establishment of this disease, its evolution, and the appearance of its different clinical forms. Metalloproteinases and their tissue inhibitors, galectins, and TGF- are involved in the process of infection and consequently the development of myocarditis, tissue remodeling, and fibrosis upon infection with .