Does play-based experience provide for inclusiveness? A case study of multi-dimensional indicators.

Playgrounds are not only for play and fun; they are places that offer diverse experiences for all groups of children. Outdoor playgrounds have been studied as an element of public space for their ability to offer an array of amenities and attributes. In addition to design and planning aspects, inclusiveness is a vital attribute of playgrounds.

Assessment of the Role of C3(HO) in the Alternative Pathway.

In this study we investigate the hydrolysis of C3 to C3(HO) and its ability to initiate activation via the alternative pathway (AP) of the complement system. The internal thioester bond within C3 is hydrolyzed by water in plasma because of its inherent lability. This results in the formation of non-proteolytically activated C3(HO) which is believed have C3b-like properties and be able to form an active initial fluid phase C3 convertase together with Factor B (FB).

Is generation of C3(HO) necessary for activation of the alternative pathway in real life?

In the alternative pathway (AP) an amplification loop is formed, which is strictly controlled by various fluid-phase and cell-bound regulators resulting in a state of homeostasis. Generation of the "C3b-like" C3(HO) has been described as essential for AP activation, since it conveniently explains how the initial fluid-phase AP convertase of the amplification loop is generated. Also, the AP has a status of being an unspecific pathway despite thorough regulation at different surfaces.