Protective effect of diosmin against diabetic neuropathy in experimental rats.

Objective: The present study was undertaken to evaluate the effect of diosmin in diabetic neuropathy in type 2 diabetic rats.

Methods: Type 2 diabetes was induced in male Sprague-Dawley rats by single intraperitoneal injection of streptozotocin (35 mg/kg) and high-fat diet. Four weeks after the confirmation of diabetes, diabetic rats were treated with diosmin (50 and 100 mg/kg, p.