Publications by authors named "Aman S Sumal"
Article Synopsis
- Gastrointestinal pain and fatigue are key issues for patients with inflammatory bowel disease (IBD), with some experiencing abdominal pain even when their disease is inactive; Ojeok-san (OJS), a medicinal herb, shows potential in alleviating this pain but lacks research in IBD preclinical models.
- * The study aimed to evaluate the analgesic effects of OJS and its potential for addiction, while also examining tumor necrosis factor alpha (TNFα) from macrophages as a factor in IBD-related pain.
- * Results indicated that OJS effectively reduced pain responses in various IBD models without exhibiting rewarding properties or being influenced by TNFα levels from macrophages, suggesting its promise as a treatment for managing pain in IBD
Circulating miRNA 887 is differentially expressed in ARDS and modulates endothelial function.
Am J Physiol Lung Cell Mol Physiol
June 2020
Circulating microRNAs (miRNAs) can be taken up by recipient cells and have been recently associated with the acute respiratory distress syndrome (ARDS). Their role in host predisposition to the syndrome is unknown. The objective of the study was to identify circulating miRNAs associated with the development of sepsis-related ARDS and examine their impact on endothelial cell gene expression and function.
View Article and Find Full Text PDFCystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which often leads to protein misfolding and no CFTR surface localization. This then leads to chronic airway infections, inflammation, and tissue damage. Although vitamin D has been explored as a therapy to treat CF due to its antimicrobial-inducing and anti-inflammatory properties, the effect of 1,25-dihydroxyvitamin D (1α,25(OH)D) on CFTR directly has not been studied.
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